| 10/16 1:00 ET | At New England | -9 | Cincinnati |
| 10/16 1:00 ET | At NY Giants | -3 | Baltimore |
| 10/16 1:00 ET | Carolina | -3 | At New Orleans |
| 10/16 1:00 ET | Pittsburgh | -7.5 | At Miami |
| 10/16 1:00 ET | At Chicago | -2.5 | Jacksonville |
| 10/16 1:00 ET | At Buffalo | -8 | San Francisco |
| 10/16 1:00 ET | At Detroit | -3.5 | Los Angeles |
| 10/16 1:00 ET | At Tennessee | -7 | Cleveland |
| 10/16 1:00 ET | Philadelphia | -2 | At Washington |
| 10/16 4:05 ET | At Oakland | -1 | Kansas City |
| 10/16 4:25 ET | At Seattle | -6.5 | Atlanta |
| 10/16 4:25 ET | At Green Bay | -4 | Dallas |
| 10/16 8:30 ET | At Houston | -3 | Indianapolis |
| 10/17 8:30 ET | At Arizona | -8 | NY Jets |
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