| 10/23 9:30 ET | NY Giants | -3 | Los Angeles (at London) |
| 10/23 1:00 ET | Minnesota | -2.5 | At Philadelphia |
| 10/23 1:00 ET | At Kansas City | -7 | New Orleans |
| 10/23 1:00 ET | At Detroit | -1 | Washington |
| 10/23 1:00 ET | At Cincinnati | -10 | Cleveland |
| 10/23 1:00 ET | Buffalo | -3 | At Miami |
| 10/23 1:00 ET | At Jacksonville | -1 | Oakland |
| 10/23 1:00 ET | At Tennessee | -2.5 | Indianapolis |
| 10/23 1:00 ET | At NY Jets | -1 | Baltimore |
| 10/23 4:05 ET | At Atlanta | -6.5 | San Diego |
| 10/23 4:05 ET | Tampa Bay | -2 | At San Francisco |
| 10/23 4:25 ET | New England | -7.5 | At Pittsburgh |
| 10/23 8:30 ET | At Arizona | -2 | Seattle |
| 10/24 8:30 ET | At Denver | -7.5 | Houston |
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