| 11/27 1:00 ET | San Diego | -1.5 | At Houston |
| 11/27 1:00 ET | Tennessee | -5 | At Chicago |
| 11/27 1:00 ET | At Buffalo | -7.5 | Jacksonville |
| 11/27 1:00 ET | At Baltimore | -4.5 | Cincinnati |
| 11/27 1:00 ET | At Atlanta | -4 | Arizona |
| 11/27 1:00 ET | At Miami | -8 | San Francisco |
| 11/27 1:00 ET | At New Orleans | -7 | Los Angeles |
| 11/27 1:00 ET | NY Giants | -7 | At Cleveland |
| 11/27 4:05 ET | Seattle | -5.5 | At Tampa Bay |
| 11/27 4:25 ET | At Oakland | -3.5 | Carolina |
| 11/27 8:30 ET | At Denver | -3.5 | Kansas City |
| 11/27 4:25 ET | New England | -8 | At NY Jets |
| 11/28 8:30 ET | At Philadelphia | -3.5 | Green Bay |
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